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Article

IGF2 associated PI3K signaling shapes temozolomide sensitivity in glioblastoma

2026-03-08

Abstract excerpt

<title>Abstract</title> <p> Resistance to temozolomide (TMZ) remains a major obstacle in glioblastoma (GBM) therapy and cannot be fully explained by canonical DNA repair mechanisms alone. Here, by integrating large scale transcriptomic datasets with machine learning based prioritization and functional validation, we identify insulin-like growth factor 2 (IGF2) as a key molecular hub linking tumor metabolic repro...

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Literature Corpus work
66c2d85f-e74a-51e9-9fce-e79aae6be11b
DOI
10.21203/rs.3.rs-8542364/v1
Open publication

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IGF2 associated PI3K signaling shapes temozolomide sensitivity in glioblastomaDOI 10.21203/rs.3.rs-8542364/v1
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