Article

Predicting gene expression from histone marks using chromatin deep learning models depends on histone mark function, regulatory distance and cellular states

2024-03-29

Abstract excerpt

To understand the complex relationship between histone mark activity and gene expression, recent advances have used in silico predictions based on large-scale machine learning models. However, these approaches have omitted key contributing factors like cell state, histone mark function or distal effects, that impact the relationship, limiting their findings. Moreover, downstream use of these models for new biolog...

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Literature Corpus work: 63296bd3-de37-5ec2-909c-cb93759800b7
DOI: 10.1101/2024.03.29.587323

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