Article

Utility of polygenic risk scores in diagnostic genetic testing for dilated cardiomyopathy

2026-01-22

Abstract excerpt

Dilated cardiomyopathy (DCM) is a major driver of heart failure and transplantation. Despite its strong genetic basis, clinical genetic testing identifies pathogenic/likely pathogenic (P/LP) variants in only about one-third of cases. Genome-wide association studies (GWAS) indicate that common variants also contribute to genetic risk, but utility of polygenic risk score (PRS) for diagnostic testing is unclear. We d...

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Literature Corpus work: 31562726-43e2-5a5b-93f5-fb3a27010290
DOI: 10.64898/2026.01.20.26344484

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