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Article

Polygenic risk and rare variants in endotypes of idiopathic pulmonary fibrosis: a genetic analysis of population-based and case-control cohorts.

The Lancet. Respiratory medicine - 1 Apr 2026

Duckworth Anna, Jackson Leigh, Green Harry, Khan Atlas, Wang Chen, Condescu Andrew, Hawkes Gareth, Noth Imre, Martinez Fernando J, Raghu Ganesh, Newton Chad A, Moll Matthew, Cho Michael, Gibbons Michael, Scotton Chris J, Kiryluk Krzysztof, Kim Garcia Christine, Zhang David

Abstract excerpt

BACKGROUND: Idiopathic pulmonary fibrosis (IPF) and telomere length are both strongly linked to rare and common genetic variants. Shortened telomere length might itself be causal for IPF. We aimed to evaluate whether rare and common variants compete or cooperate to confer genetic risk of IPF uniformly. METHODS: In this genetic analysis, we used whole-genome sequencing (WGS) data from a discovery case-control...

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Identifiers

PMID: 41616791
DOI: 10.1016/S2213-2600(25)00405-9
PMCID: PMC12952213

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MUC5B

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