Article

All-FIT: Allele-Frequency-based Imputation of Tumor Purity from High-Depth Sequencing Data

2019-05-02

Abstract excerpt

<h4>Motivation</h4> Clinical sequencing aims to identify somatic mutations in cancer cells for accurate diagnosis and treatment. However, most widely used clinical assays lack patient-matched control DNA and additional analysis is needed to distinguish somatic and unfiltered germline variants. Such computational analyses require accurate assessment of tumor cell content in individual specimens. Histological estim...

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Literature Corpus work: 663d4f5d-5bcc-514c-9ca3-2726f96ca963
DOI: 10.1101/625376

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