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Article

STIC: Predicting Single Nucleotide Variants and Tumor Purity in Cancer Genome.

IEEE/ACM transactions on computational biology and bioinformatics - 1 Jan 2000

Yuan Xiguo, Ma Chao, Zhao Haiyong, Yang Liying, Wang Shuzhen, Xi Jianing

Abstract excerpt

Single nucleotide variant (SNV) plays an important role in cellular proliferation and tumorigenesis in various types of human cancer. Next-generation sequencing (NGS) has provided high-throughput data at an unprecedented resolution to predict SNVs. Currently, there exist many computational methods for either germline or somatic SNV discovery from NGS data, but very few of them are versatile enough to adapt to any...

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PMID: 32086221
DOI: 10.1109/TCBB.2020.2975181

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