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Article

Metastatic colorectal adenocarcinoma tumor purity assessment from whole exome sequencing data.

PloS one - 1 Jan 2023

Tbeileh Noura, Timmerman Luika, Mattis Aras N, Toriguchi Kan, Kasai Yosuke, Corvera Carlos, Nakakura Eric, Hirose Kenzo, Donner David B, Warren Robert S, Karelehto Eveliina

Abstract excerpt

Tumors rich in stroma are associated with advanced stage and poor prognosis in colorectal adenocarcinoma (CRC). Abundance of stromal cells also has implications for genomic analysis of patient tumors as it may prevent detection of somatic mutations. As part of our efforts to interrogate stroma-cancer cell interactions and to identify actionable therapeutic targets in metastatic CRC, we aimed to determine the...

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PMID: 37022995
DOI: 10.1371/journal.pone.0271354
PMCID: PMC10079084

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