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A novel mouse allele of the DNA/RNA helicase senataxin ( <i> Setx <sup>spcar3</sup> </i> ) causing meiotic arrest of spermatocytes and male infertility

2023-04-13

Abstract excerpt

<h4>ABSTRACT</h4> An unbiased screen for discovering novel genes for fertility identified the spcar3, spermatocyte arrest 3, mutant phenotype. The spcar3 mutation identified a new allele of the Setx gene, encoding senataxin, a DNA/RNA helicase that regulates transcription termination by resolving DNA/RNA hybrid R-loop structures. Although mutations in the human SETX gene cause neural disorders, Setx spcar3...

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Literature Corpus work
6636d7c2-8dac-52e7-bf52-1e200cb1d9dd
DOI
10.1101/2023.04.12.536672
Open publication

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A novel mouse allele of the DNA/RNA helicase senataxin ( <i> Setx <sup>spcar3</sup> </i> ) causing meiotic arrest of spermatocytes and male infertilityDOI 10.1101/2023.04.12.536672
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