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New allele of mouse DNA/RNA helicase senataxin causes meiotic arrest and infertility.

Reproduction (Cambridge, England) - 1 Dec 2023

Fujiwara Yasuhiro, Saito Kouhei, Sun Fengyun, Petri Sabrina, Inoue Erina, Schimenti John, Okada Yuki, Handel Mary Ann

Abstract excerpt

In brief: A new allele of the senataxin gene Setxspcar3 causes meiotic arrest of spermatocytes with aberrant DNA damage and accumulation of R-loops. Abstract: An unbiased screen for discovering novel mouse genes for fertility identified the spcar3, spermatocyte arrest 3, mutant phenotype. The spcar3 mutation identified a new allele of the Setx gene, encoding senataxin, a DNA/RNA helicase that regulates...

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Identifiers

PMID: 37801077
DOI: 10.1530/REP-23-0166

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