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Article

Premature ovarian ageing following heterozygous loss of Senataxin.

Molecular human reproduction - 5 Feb 2021

Subramanian G N, Lavin M, Homer H A

Abstract excerpt

Premature loss of ovarian activity before 40 years of age is known as primary ovarian insufficiency (POI) and occurs in ∼1% of women. A more subtle decline in ovarian activity, known as premature ovarian ageing (POA), occurs in ∼10% of women. Despite the high prevalence of POA, very little is known regarding its genetic causation. Senataxin (SETX) is an RNA/DNA helicase involved in repair of oxidative...

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PMID: 33337500
DOI: 10.1093/molehr/gaaa080

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