Article
CRISPR/Cas9 Promotes Functional Study of Testis Specific X-Linked Gene In Vivo.
PloS one - 1 Jan 2015
Li Minyan, Huang Rui, Jiang Xue, Chen Yuxi, Zhang Zhen, Zhang Xiya, Liang Puping, Zhan Shaoquan, Cao Shanbo, Songyang Zhou, Huang Junjiu
Abstract excerpt
Mammalian spermatogenesis is a highly regulated multistage process of sperm generation. It is hard to uncover the real function of a testis specific gene in vitro since the in vitro model is not yet mature. With the development of the CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR-associated 9) system, we can now rapidly generate knockout mouse models of testis specific genes to...
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