Article

Early cell cycle genes in cortical organoid progenitors predict interindividual variability in infant brain growth trajectories

2025-02-08

Abstract excerpt

<h4>Summary</h4> Human induced pluripotent stem cell (iPSC) derived cortical organoids (hCOs) model neurogenesis on an individual’s genetic background. The degree to which hCO phenotypes recapitulate the brain growth of the participants from which they were derived is not well established. We generated up to 3 iPSC clones from each of 18 participants in the Infant Brain Imaging Study, who have undergone longitudi...

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Literature Corpus work: 661997f5-89b4-5abd-b68c-0fa01944c1f3
DOI: 10.1101/2025.02.07.637106

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