Article

Cell Type-Agnostic Transcriptomic Signatures Enable Uniform Comparisons of Neurodevelopment

2025-02-25

Abstract excerpt

<h4>Summary</h4> Single-cell transcriptomics has revolutionized our understanding of neurodevelopmental cell identities, yet, predicting a cell type’s developmental state from its transcriptome remains a challenge. We perform a meta-analysis of developing human brain datasets comprising over 2.8 million cells, identifying both tissue-level and cell-autonomous predictors of developmental age. While tissue composit...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1cf20508-7ede-5ae1-8e34-bfabce3ec101
DOI: 10.1101/2025.02.24.639936

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cell Type-Agnostic Transcriptomic Signatures Enable Uniform Comparisons of NeurodevelopmentDOI 10.1101/2025.02.24.639936Read

A consensus atlas of human brain development defines cell type-specific maturation trajectories across the lifespanSemantic proximity Read

NeuRoDev resolves lifelong temporal and cellular variation in human cortical gene expressionSemantic proximity Read

A single cell transcriptomic analysis of human neocortical developmentSemantic proximity Read

Deciphering Cell-Type and Temporal-Specific Matrisome Expression Signatures in Human Cortical Development and Neurodevelopmental Disorders via scRNA-Seq Meta-AnalysisSemantic proximity Read

Single-cell multiomics atlas of organoid development uncovers longitudinal molecular programs of cellular diversification of the human cerebral cortexSemantic proximity Read

An integrative single-cell atlas to explore the cellular and temporal specificity of neurological disorder genes during human brain developmentSemantic proximity Read

Single-cell transcriptomic catalog of mouse cortical developmentSemantic proximity Read

Comprehensive cell atlas of the first-trimester developing human brainSemantic proximity Read

Preservation of co-expression defines the primary tissue fidelity of human neural organoidsSemantic proximity Read

Human brain organoids record the passage of time over multiple years in cultureSemantic proximity Read

Neurodevelopmental disorders-high-resolution rethinking of disease modeling.Semantic proximity Read

A comprehensive view of cell-type-specific temporal dynamics in human and mouse brainsSemantic proximity Read