p53 alterations in human cancer: more questions than answers.

doi:10.1038/sj.onc.1210280

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Article

p53 alterations in human cancer: more questions than answers.

Oncogene - 2 Apr 2007

Soussi T

Abstract excerpt

The strongest and undisputed fact about p53 is the high frequency of p53 alterations in human cancer and that mutant p53 proteins constitute a complex family of several hundred proteins with heterogeneous properties. Beyond these observations, the p53 pathway and its regulation in a normal cell is like a desert trail, always moving with the wind of novel findings. The field is full of black boxes that are often...

Topics

Adaptor Proteins, Signal Transducing
Animals
Apoptosis Regulatory Proteins
Binding Sites
Carrier Proteins
DNA Methylation
Disease Models, Animal
Humans
Mice
Mutation
Neoplasms
Protein Structure, Tertiary
Tumor Suppressor Protein p53
bcl-X Protein

Source

Open in PubMed

Identifiers

PMID: 17401423
DOI: 10.1038/sj.onc.1210280

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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