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Discovery of some phenylhydrazones as potential antimalarials: An integrated computational approach on PfATP6 and PfDHFR mutant proteins

2024-03-14

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold> <italic>Plasmodium falciparum</italic> resistance to artemisinins and anti-folate pyrimethamine has hampered WHO efforts in the global eradication of malaria. Several studies have linked artemisinin and pyrimethamine resistance to mutations in the PfATP6 (calcium ATPase) and PfDHFR (dihydrofolate reductase) genes, respectively. However, the mechanism of resistanc...

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Literature Corpus work
660502ac-7864-5733-be83-eaeb5acac283
DOI
10.21203/rs.3.rs-4057743/v1
Open publication

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Discovery of some phenylhydrazones as potential antimalarials: An integrated computational approach on PfATP6 and PfDHFR mutant proteinsDOI 10.21203/rs.3.rs-4057743/v1
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