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Article

Resistance to antifolates in Plasmodium falciparum, the causative agent of tropical malaria.

Science progress - 1 Jan 2002

Warhurst David C

Abstract excerpt

Every year there are 270 million clinical attacks of malaria and 2 million deaths, caused by the protozoan Plasmodium falciparum. Most of these cases occur in Africa. Chloroquine-resistance has led to reliance on anti-malarial antifolates, in particular the synergistic combination sulfadoxine/pyrimethamine (S/P) which targets enzymatic synthesis of folate co-factors through dihydropteroate synthase (DHPS) and...

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Source

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Identifiers

PMID: 11969121
DOI: 10.3184/003685002783238906
PMCID: PMC10367537

Genes

DHFR
DHPS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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