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Article

Docking and database screening reveal new classes of Plasmodium falciparum dihydrofolate reductase inhibitors.

Journal of medicinal chemistry - 3 Jul 2003

Rastelli Giulio, Pacchioni Sara, Sirawaraporn Worachart, Sirawaraporn Rachada, Parenti Marco Daniele, Ferrari Anna Maria

Abstract excerpt

Plasmodium falciparum dihydrofolate reductase (PfDHFR) is an important target for antimalarial chemotherapy. Unfortunately, the emergence of resistant parasites has significantly reduced the efficiency of classical antifolate drugs such as cycloguanil and pyrimethamine. In this study, an approach toward molecular docking of the structures contained in the Available Chemicals Directory (ACD) database to search for...

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PMID: 12825927
DOI: 10.1021/jm030781p

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ACD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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