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Plasmodium falciparum Histo-Aspartic Protease (HAP) inhibitor: Toxicity Investigation and Docking Study of 2-(2-benzoyl-4-methylphenoxy)quinoline-3-carbaldehyde derivatives

2023-03-30

Abstract excerpt

<title>Abstract</title> Aspartic proteases possess catalytic sites for hydrolysis of peptide bonds which makes them potentials drug target in the malaria parasites. Inhibiting Histo-Aspartic Protease (HAP), aspartate (Asp215) and histidine (His32) residues of the <italic>P. falciparum</italic> disrupts the growth phase and ability to catalyse erythrocyte hemoglobin degradation. We synthes...

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Literature Corpus work: 94b4a39a-a08c-5cc9-8a01-ad0f3695fda2
DOI: 10.21203/rs.3.rs-2748975/v1

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Plasmodium falciparum Histo-Aspartic Protease (HAP) inhibitor: Toxicity Investigation and Docking Study of 2-(2-benzoyl-4-methylphenoxy)quinoline-3-carbaldehyde derivativesDOI 10.21203/rs.3.rs-2748975/v1Read

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