Article
Generation of multi-lineage kidney assembloids with integration between nephrons and a single exiting collecting duct
2025-03-01
Abstract excerpt
A functional kidney requires a patent connection between all nephrons and the collecting duct network to ensure an exit path for the urinary filtrate. While it is now possible to separately direct the differentiation of pluripotent stem cells to nephron-forming or nephric duct-forming populations, the controlled integration of these two systems has not been demonstrated in human. We report the formation of an inte...
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Identifiers and source
- Literature Corpus work
- 20c8c90c-df48-5978-918d-098350a2c8b5
- DOI
- 10.1101/2025.02.27.640561