Article

Fate-mapping within human kidney organoids reveals conserved mammalian nephron progenitor lineage relationships

2018-10-01

Abstract excerpt

While mammalian kidney morphogenesis has been well documented, human kidney development is poorly understood. Here we combine reprogramming, CRISPR/Cas9 gene-editing and organoid technologies to study human nephron lineage relationships in vitro . Early kidney organoids contained a SIX2 + population with a transcriptional profile akin to human nephron progenitors. Lineage-tracing using gene-edited induced plurip...

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Literature Corpus work: 823229c2-2024-5a92-909f-4a6147929d81
DOI: 10.1101/432161

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