Article

A Mathematical Model for On-Target Off-Tumor Effect of CAR-T Cells on Gliomas

2022-07-14

Abstract excerpt

CAR-T cell immunotherapy involves genetically reprogrammed T-lymphocytes that interact with cancer cells and activate an anti-tumor immune response. This therapy has been approved for clinical use for hematological cancers, but new challenges have emerged in the treatment of solid tumors. Some of the challenges include the heterogeneity of antigen expression found in solid tumors, including antigen-positive non-tu...

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Literature Corpus work: 65e658ef-0580-5ac4-92ef-79567193637c
DOI: 10.3389/fsysb.2022.923085

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