Article

Neoantigens and Stochastic Fluctuations Regulate T Cell Proliferation in Primary and Metastatic Malignant Brain Tumors

2025-04-26

Abstract excerpt

Brain cancer is one of the most aggressive forms of cancer in the central nervous system occurring as primary or metastatic tumors. Sequencing of resected tissues from glioblastoma (GBM) and brain metastases (BrMET) reveals high heterogeneity in neoantigens and T cell receptor (TCR) repertoires. Our analysis of published sequencing data in different spatial regions of tumors GBM and BrMET patients show the presenc...

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Literature Corpus work: 2401abbc-d822-5b53-beb8-a9985131f631
DOI: 10.1101/2025.04.23.650340

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