Article

Endogenous bystander killing mechanisms enhance the activity of novel FAP-specific CAR-T cells against glioblastoma

2023-02-22

Abstract excerpt

<h4>Objectives</h4> CAR-T cells are being investigated as a novel immunotherapy for glioblastoma, but clinical success has been limited. We recently described fibroblast activation protein (FAP) as an ideal target antigen for glioblastoma immunotherapy, with expression on both tumor cells and tumor blood vessels. However, CAR-T cells targeting FAP have never been investigated as a therapy for glioblastoma. <h4>Me...

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Literature Corpus work: bc400708-91c0-5eb3-af37-e60ecdd160b0
DOI: 10.1101/2023.02.21.529331

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