Dual-Target Car-Ts With on- and off-Tumour Activity May Override Immune Suppression in Solid Cancers: A Mathematical Proof of Concept

Abstract excerpt

Chimeric antigen receptor (CAR)-T cell-based therapies have achieved substantial successes against B-cell malignancies, what has led to a growing scientific and clinical interest on extending their use to solid cancers. However, results for solid tumours have been limited up to now, in part due to the immuno-suppressive tumour microenvironment, that is able to inactivate CAR-T cell clones. In this paper we put for...

Topics

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• CAR-T cell therapy research
• Genotype
• Immunotherapy
• Models, Theoretical
• Monoclonal and Polyclonal Antibodies Research
• Mutation
• Nanowire Synthesis and Applications
• Neoplasms

Identifiers and source

Literature Corpus work

9033c8ea-21d7-5d72-af8e-4105e01db620

DOI

10.20944/preprints202012.0166.v1