Article

A chromatin modulator sustains self-renewal and enables differentiation of postnatal neural stem and progenitor cells

2019-02-18

Abstract excerpt

<h4>ABSTRACT</h4> It remains unknown whether H3K4 methylation, an epigenetic modification associated with gene activation, regulates fate determination of the postnatal neural stem and progenitor cells (NSCs and NPCs, or NSPCs). Here we show that the Dpy30 subunit of the major H3K4 methyltransferase complexes is preferentially expressed at a high level in NSCs and NPCs. By genetically inactivating Dpy30 in specif...

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Literature Corpus work: 65d5433d-c144-5563-a583-a197aaaa2667
DOI: 10.1101/554535

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