Article
Targeted deletion of the murine corneodesmosin gene delineates its essential role in skin and hair physiology.
Proceedings of the National Academy of Sciences of the United States of America - 6 May 2008
Matsumoto Mitsuru, Zhou Yiqing, Matsuo Shinji, Nakanishi Hideki, Hirose Kenji, Oura Hajimu, Arase Seiji, Ishida-Yamamoto Akemi, Bando Yoshimi, Izumi Keisuke, Kiyonari Hiroshi, Oshima Naoko, Nakayama Rika, Matsushima Akemi, Hirota Fumiko, Mouri Yasuhiro, Kuroda Noriyuki, Sano Shigetoshi, Chaplin David D
Abstract excerpt
Controlled proteolytic degradation of specialized junctional structures, corneodesmosomes, by epidermal proteases is an essential process for physiological desquamation of the skin. Corneodesmosin (CDSN) is an extracellular component of corneodesmosomes and, although considerable debate still exists, genetic studies have suggested that the CDSN gene in the major psoriasis-susceptibility locus (PSORS1) may be...
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