Article
Th17-skewed inflammation due to genetic deficiency of a cadherin stress sensor
2020-12-02
Abstract excerpt
Desmoglein 1 (Dsg1) is a cadherin restricted to stratified tissues of terrestrial vertebrates, which serve as essential physical and immune barriers. Dsg1’s importance in epidermal integrity is underscored by genetic, autoimmune and bacterial toxin-mediated disorders interfering with Dsg1 function. Dsg1 loss-of-function mutations in humans result not only in skin lesions, but also multiple allergies, and isolated...
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Identifiers and source
- Literature Corpus work
- 4c492515-8375-56df-a536-8033f17725fb
- DOI
- 10.1101/2020.12.01.406587