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Article

NADPH oxidase 4 is dispensable for skin myofibroblast differentiation and wound healing

13 Jan 2023

Abstract excerpt

Differentiation of fibroblasts to myofibroblasts is governed by the transforming growth factor beta (TGF-β) through a mechanism involving redox signaling and generation of reactive oxygen species (ROS). Myofibroblasts synthesize proteins of the extracellular matrix (ECM) and display a contractile phenotype. Myofibroblasts are predominant contributors of wound healing and several pathological states, including...

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PMID: 36708644
DOI: 10.1016/j.redox.2023.102609

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