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Article

Targeting Fibrosis in Duchenne Muscular Dystrophy

7 Jul 2010

Abstract excerpt

Duchenne muscular dystrophy (DMD) is the most common genetic muscle disease affecting 1 in 3,500 live male births. It is an X-linked recessive disease caused by a defective dystrophin gene. The disease is characterized by progressive limb weakness, respiratory and cardiac failure, and premature death. Fibrosis is a prominent pathological feature of muscle biopsies from patients with DMD. It directly causes muscle...

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PMID: 20613637
DOI: 10.1097/nen.0b013e3181e9a34b

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