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Article

Silencing Nfix rescues muscular dystrophy by delaying muscle regeneration

16 Oct 2017

Abstract excerpt

Muscular dystrophies are severe disorders due to mutations in structural genes, and are characterized by skeletal muscle wasting, compromised patient mobility, and respiratory functions. Although previous works suggested enhancing regeneration and muscle mass as therapeutic strategies, these led to no long-term benefits in humans. Mice lacking the transcription factor Nfix have delayed regeneration and a shift...

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PMID: 29057908
DOI: 10.1038/s41467-017-01098-y

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