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Article

The skeletal muscle phenotype of the DE50-MD dog model of Duchenne muscular dystrophy

23 Sept 2022

Abstract excerpt

<h4>Background: </h4> : Animal models of Duchenne muscular dystrophy (DMD) are essential to study disease progression and assess efficacy of therapeutic intervention, however dystrophic mice fail to display a clinically relevant phenotype, limiting translational utility. Dystrophin-deficient dogs exhibit disease similar to humans, making them increasingly important for late-stage preclinical evaluation of...

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PMID: 36865375
DOI: 10.12688/wellcomeopenres.18251.1

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