Article

Single-molecule nanopore dielectrophoretic trapping of α-Synuclein with lipid membranes

2022-01-24

Abstract excerpt

<h4>ABSTRACT</h4> The lipid-α-Synuclein (α-Syn) interaction plays a crucial role in the pathogenesis of Parkinson’s disease. Here, we trap α-Syn at a conjunction of an α-hemolysin (αHL) single nanopore-lipid to investigate the folding and unfolding kinetics of α-Syn in a lipidic environment. The hybridized α-Syn is generated through a reaction between a 5’-thiol-modified nucleotide oligo (dC30) and the α-Syn muta...

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Literature Corpus work: 65a6a32f-3455-56fd-9b30-0b95668785d6
DOI: 10.1101/2022.01.24.477462

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