Article

Integrated Omics Approach to Delineate the Mechanisms of Doxorubicin-Induced Cardiotoxicity

2025-06-27

Abstract excerpt

Doxorubicin (DOX) is an effective chemotherapy whose clinical utility is limited by cardiotoxicity. To investigate underlying mechanisms, we employed a multi-omics approach integrating transcriptomic and proteomic profiling leveraging established mouse models of chronic DOX- induced cardiotoxicity. Five-week-old male mice received weekly DOX (4 mg/kg) or saline injections for six weeks, with heart tissues harveste...

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Literature Corpus work: fa9f73fd-7aff-523e-b6ff-de90e5b53937
DOI: 10.1101/2025.06.24.661365

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