Article

Progressive suppression of DNA repair genes with persistent p53 activation in Doxorubicin-treated cardiomyocytes

2026-02-06

Abstract excerpt

Doxorubicin (DOX) is an effective anti-cancer drug; however it can cause cardiotoxicity by inducing DNA double-strand breaks in cardiomyocytes. Cardiotoxicity can manifest immediately or years following treatment. Most human in vitro models of DOX-induced cardiotoxicity (DIC) focus on the acute effects of DOX treatment. To understand the long-term effects, we profiled the global gene expression response to DOX ex...

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Literature Corpus work: 7eaab989-8b92-5b0b-9622-3df800d90658
DOI: 10.64898/2026.02.03.703628

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