Article

Highly parameterized polygenic scores tend to overfit to population stratification via random effects

2024-01-29

Abstract excerpt

Polygenic scores (PGSs), increasingly used in clinical settings, frequently include many genetic variants, with performance typically peaking at thousands of variants. Such highly parameterized PGSs often include variants that do not pass a genome-wide significance threshold. We propose a mathematical perspective that renders the effects of many of these nonsignificant variants random rather than causal, with the...

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Identifiers and source

Literature Corpus work: 65694111-b067-5f30-80a1-01d47fd41412
DOI: 10.1101/2024.01.27.577589

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