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IDHwt glioblastomas can be stratified by their transcriptional response to standard treatment, with implications for targeted therapy

2023-02-03

Abstract excerpt

Glioblastoma (GBM) brain tumours lacking IDH1 mutations (IDHwt) have the worst prognosis of all brain neoplasms. Patients receive surgery and chemoradiotherapy but tumours almost always fatally recur. Using RNAseq data from 107 pairs of pre- and post-standard treatment locally recurrent IDHwt GBM tumours, we identified two responder subtypes based on therapy-driven changes in gene expression. In two thirds of pat...

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Literature Corpus work
655c4f04-9f61-536a-aa8e-854ac64b2751
DOI
10.1101/2023.02.03.526945
Open publication

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IDHwt glioblastomas can be stratified by their transcriptional response to standard treatment, with implications for targeted therapyDOI 10.1101/2023.02.03.526945
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