Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IDHwt glioblastomas can be stratified by their transcriptional response to standard treatment, with implications for targeted therapy

7 Feb 2024

Abstract excerpt

BACKGROUND: Glioblastoma (GBM) brain tumors lacking IDH1 mutations (IDHwt) have the worst prognosis of all brain neoplasms. Patients receive surgery and chemoradiotherapy but tumors almost always fatally recur. RESULTS: Using RNA sequencing data from 107 pairs of pre- and post-standard treatment locally recurrent IDHwt GBM tumors, we identify two responder subtypes based on longitudinal changes in gene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Genomics and Chromatin Dynamics
Share to Glioma Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38326875
DOI: 10.1186/s13059-024-03172-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IDHwt glioblastomas can be stratified by their transcriptional response to standard treatment, with implications for targeted therapyPMID 38326875Read ↗

IDHwt glioblastomas can be stratified by their transcriptional response to standard treatment, with implications for targeted therapySemantic proximity Read ↗

Longitudinal analysis of diffuse glioma reveals cell state dynamics at recurrence associated with changes in genetics and the microenvironmentSemantic proximity Read ↗

Transcriptional diversity of long-term glioblastoma survivors.Semantic proximity Read ↗

Epigenetic mechanisms of plasticity and resistance in glioblastoma: therapeutic targets and implicationsSemantic proximity Read ↗

JARID2 facilitates transcriptional reprogramming in glioblastoma in response to standard treatmentSemantic proximity Read ↗

The Epigenetic Evolution of Glioma Is Determined by the IDH1 Mutation Status and Treatment Regimen.Semantic proximity Read ↗

Glioma progression is shaped by genetic evolution and microenvironment interactions.Semantic proximity Read ↗

Overcoming therapeutic resistance in glioblastoma: the way forwardSemantic proximity Read ↗

Longitudinal multimodal profiling of IDH-wildtype glioblastoma reveals the molecular evolution and cellular phenotypes underlying prognostically different treatment responsesSemantic proximity Read ↗

Evolving cell states and oncogenic drivers during the progression of IDH-mutant gliomas.Semantic proximity Read ↗

Intratumoral Heterogeneity and Longitudinal Changes in Gene Expression Predict Differential Drug Sensitivity in Newly Diagnosed and Recurrent GlioblastomaSemantic proximity Read ↗

Mapping chromatin remodelling in glioblastoma identifies epigenetic regulation of key molecular pathways and novel druggable targetsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.