Article

STK11 loss leads to YAP1-mediated transcriptional activation in human KRAS-driven lung adenocarcinoma cell lines

2023-07-07

Abstract excerpt

<title>Abstract</title> <p>Serine Threonine Kinase 11 (STK11) loss of function (LoF) correlates with anti-PD-1 therapy resistance in patients with KRAS-driven lung adenocarcinoma (LUAD). The molecular mechanisms governing this observation remain unclear and represent a critical outstanding question in the field of lung oncology. As an initial approach to understand this phenomenon, we knocked out <italic>STK11</i...

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Literature Corpus work: 6541d19f-950a-5572-ad4a-c7ca0557e352
DOI: 10.21203/rs.3.rs-3113344/v1

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