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Article

STK11 mutation impacts CD1E expression to regulate the differentiation of macrophages in lung adenocarcinoma.

Immunity, inflammation and disease - 1 Jul 2023

Zhang Qingfeng, Feng Juan, Liu Kui, Yang Xiaoyan, Huang Yun, Tang Bo

Abstract excerpt

BACKGROUND: The deficiency of serine/threonine protein kinase 11 (STK11), one of the most common tumor suppressor genes in non-small-cell lung cancer, is a crucial player in tumor immune microenvironment regulation. This study attempted to unveil how mutated STK11 impact the differentiation of macrophages in lung adenocarcinoma (LUAD). METHODS: STK11 and CD1E expression levels in different cell models were...

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Identifiers

PMID: 37506141
DOI: 10.1002/iid3.958
PMCID: PMC10373563

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