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Article

Prevalence and clinico-morphological correlates of STK11 mutations in a large cohort of NSCLC lung adenocarcinomas.

Virchows Archiv : an international journal of pathology - 1 Jul 2026

Rustamov Rizvan, Füzesi László, Lesser Thomas, Täuscher Dagmar, Funke Uwe, Elsner Peter, Mireskandari Masoud, Kristiansen Glen, Petersen Iver

Abstract excerpt

STK11-mutated non-small cell lung cancers (NSCLC) show distinct clinicopathologic features, often with co-occurring KRAS and TP53 mutations that drive more aggressive disease. This study investigates the mutational landscape and clinical characteristics of STK11-mutated lung adenocarcinomas. We retrospectively reviewed 1,068 primary lung cancer cases from 2018 to 2022, identifying 14 STK11-mutant lung...

Topics

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Biomarkers, Tumor
Adenocarcinoma of Lung
AMP-Activated Protein Kinase Kinases
Carcinoma, Non-Small-Cell Lung
Prevalence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Serine-Threonine Kinases

Proto-Oncogene Proteins p21(ras)

Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 41549133
DOI: 10.1007/s00428-025-04392-z
PMCID: PMC13369655

Genes

STK11
KRAS
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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