Article

Pathway-specific Polygenic Risk Scores (PRS) identify OSA-related pathways differentially moderating genetic susceptibility to CAD

2021-04-30

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Obstructive sleep apnea (OSA) and its features, such as chronic intermittent hypoxia (IH), may differentially affect specific molecular pathways and processes in the pathogenesis of coronary artery disease (CAD) and influence the subsequent risk and severity of CAD events. In particular, competing adverse (e.g. inflammatory) and protective (e.g. increased coronary collateral b...

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Literature Corpus work: 6537af61-682a-5418-97ca-44562348dfca
DOI: 10.1101/2021.04.27.21255520

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