Polygenic scores for obstructive sleep apnoea reveal pathways contributing to cardiovascular disease.

doi:10.1016/j.ebiom.2025.105790

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Article

Polygenic scores for obstructive sleep apnoea reveal pathways contributing to cardiovascular disease.

EBioMedicine - 1 Jul 2025

Kurniansyah Nuzulul, Strausz Satu J, Chittoor Geetha, Gupta Shreyash, Justice Anne E, Hrytsenko Yana, Keenan Brendan T, Cade Brian E, Spitzer Brian W, Wang Heming, Huffman Jennifer, Moll Matthew R, Haring Bernhard, Jung Su Yon, Raffield Laura M, Kaplan Robert, Rotter Jerome I, Rich Stephen S, Gharib Sina A, Bartz Traci M, Liu Peter Y, Chen Han, Fornage Myriam, Hou Lifang, Levy Daniel, Morrison Alanna C, Ochs-Balcom Heather M, Psaty Bruce M, Wilson Peter W F, Cho Kelly, Pack Allan I, Ollila Hanna M, Redline Susan, Gottlieb Daniel J, Sofer Tamar

Abstract excerpt

BACKGROUND: Obstructive sleep apnoea (OSA) is a common chronic condition, with obesity its strongest risk factor. Polygenic scores (PGSs) summarise the genetic liability to phenotype and can provide insights into relationships between phenotypes. Recently, large datasets that include genetic data...

Topics

Humans
Sleep Apnea, Obstructive
Female
Male
Cardiovascular Diseases
Multifactorial Inheritance
Genetic Predisposition to Disease
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Aged

Body Mass Index

Risk Factors

Phenotype

Odds Ratio

Polymorphism, Single Nucleotide

Obesity

Source

Open in PubMed Open full text

Identifiers

PMID: 40472801
DOI: 10.1016/j.ebiom.2025.105790
PMCID: PMC12171572

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-40472801-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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