Polygenic scores for obstructive sleep apnoea reveal pathways contributing to cardiovascular disease.

doi:10.1016/j.ebiom.2025.105790

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Article

Polygenic scores for obstructive sleep apnoea reveal pathways contributing to cardiovascular disease.

EBioMedicine - 1 Jul 2025

Kurniansyah Nuzulul, Strausz Satu J, Chittoor Geetha, Gupta Shreyash, Justice Anne E, Hrytsenko Yana, Keenan Brendan T, Cade Brian E, Spitzer Brian W, Wang Heming, Huffman Jennifer, Moll Matthew R, Haring Bernhard, Jung Su Yon, Raffield Laura M, Kaplan Robert, Rotter Jerome I, Rich Stephen S, Gharib Sina A, Bartz Traci M, Liu Peter Y, Chen Han, Fornage Myriam, Hou Lifang, Levy Daniel, Morrison Alanna C, Ochs-Balcom Heather M, Psaty Bruce M, Wilson Peter W F, Cho Kelly, Pack Allan I, Ollila Hanna M, Redline Susan, Gottlieb Daniel J, Sofer Tamar

Abstract excerpt

BACKGROUND: Obstructive sleep apnoea (OSA) is a common chronic condition, with obesity its strongest risk factor. Polygenic scores (PGSs) summarise the genetic liability to phenotype and can provide insights into relationships between phenotypes. Recently, large datasets that include genetic data and OSA status became available, providing an opportunity to utilise PGS approaches to study the genetic relationship...

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Identifiers

PMID: 40472801
DOI: 10.1016/j.ebiom.2025.105790
PMCID: PMC12171572

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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