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Article

Pathway-Specific Polygenic Risk Scores Identify Obstructive Sleep Apnea-Related Pathways Differentially Moderating Genetic Susceptibility to Coronary Artery Disease.

Circulation. Genomic and precision medicine - 1 Oct 2022

Goodman Matthew O, Cade Brian E, Shah Neomi A, Huang Tianyi, Dashti Hassan S, Saxena Richa, Rutter Martin K, Libby Peter, Sofer Tamar, Redline Susan

Abstract excerpt

BACKGROUND: Obstructive sleep apnea (OSA) and its features, such as chronic intermittent hypoxia, may differentially affect specific molecular pathways and processes in the pathogenesis of coronary artery disease (CAD) and influence the subsequent risk and severity of CAD events. In particular, competing adverse (eg, inflammatory) and protective (eg, increased coronary collateral blood flow) mechanisms may...

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Identifiers

PMID: 36170352
DOI: 10.1161/CIRCGEN.121.003535
PMCID: PMC9588629

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