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Local Metabolic-Hypoxic Conditioning as a Spatial Modulator of Immune-Mediated Tissue Injury: A Systems Framework with Application to Multiple Sclerosis

2026-03-06

Abstract excerpt

Immune-mediated tissue injury is typically conceptualized as a consequence of aberrant immune activation; however, spatial patterns of lesion formation and selective tissue vulnerability across diseases suggest that immune activity alone may not determine where damage becomes established. We propose a generalizable systems framework in which regional metabolic preconditioning, defined by local perfusion dynamics,...

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Literature Corpus work
6528a860-05c3-54f0-9b79-3d885c0da58e
DOI
10.20944/preprints202603.0492.v1
Open publication

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Local Metabolic-Hypoxic Conditioning as a Spatial Modulator of Immune-Mediated Tissue Injury: A Systems Framework with Application to Multiple SclerosisDOI 10.20944/preprints202603.0492.v1
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