Article

Glandular architecture and malignant behaviour in colorectal cancer is regulated by the sialomucin Podocalyxin.

2026-07-10

Abstract excerpt

Glandular architecture - the coordination of lumen-containing structures by an apical-basal polarised epithelium - is frequently maintained in colorectal cancer (CRC), yet whether it actively contributes to tumour progression or metastatic competence remains unclear. Here, we identify Podocalyxin (PODXL), a developmental regulator of epithelial lumen formation, as a key determinant of glandular tumour architecture...

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Literature Corpus work: 65006548-022f-5961-bf42-abc144835893
DOI: 10.64898/2026.07.10.737619

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