Article

Cell State Chaos Underpins the Evolution of SMARCA4-Deficient Dedifferentiated Endometrial Cancer

2025-12-03

Abstract excerpt

<h4>ABSTRACT</h4> Dedifferentiated endometrial carcinoma (DDEC) is a histologically unique cancer type, wherein well-differentiated regions lie adjacent to morphologically distinct, high-grade lesions that are histologically undifferentiated. Previous studies have determined that in nearly half of the cases dedifferentiation is associated with the genomic inactivation of SMARCA4 , a catalytic subunit belonging t...

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Literature Corpus work: 64ffcbff-ffbd-5098-a460-52620741255f
DOI: 10.64898/2025.12.01.690470

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