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Article

Molecular subtypes and genomic landscape of undifferentiated and dedifferentiated endometrial cancer.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society - 1 May 2025

Dagher Christian, Selenica Pier, Momeni-Boroujeni Amir, Ellenson Lora H, Mueller Jennifer J, Abu-Rustum Nadeem R, Chui M Herman, Weigelt Britta

Abstract excerpt

OBJECTIVE: Undifferentiated and dedifferentiated endometrial carcinomas are rare and clinically aggressive variants of the disease. We sought to define the molecular subtypes and genetic alterations affecting cancer-related genes of these rare histologic endometrial cancer types. METHODS: Patients with undifferentiated/dedifferentiated endometrial cancer subjected to clinical tumor-normal panel sequencing between...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40288099
DOI: 10.1016/j.ijgc.2025.101815
PMCID: PMC13094064

Genes

ARID1A
ARID1B
PIK3CA
POLE
PTEN
SMARCA4
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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