Article

Integrating External Controls by Regression Calibration for Genome-Wide Association Study

2023-12-15

Abstract excerpt

Genome-wide association studies (GWAS) have successfully revealed many disease-associated genetic variants. For a case-control study, the adequate power of an association test can be achieved with a large sample size, although genotyping large samples is expensive. A cost‐effective strategy to boost power is to integrate external control samples with publicly available genotyped data. However, the naïve integratio...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 64e7c4c4-38be-596b-83e1-115d76d86cc6
DOI: 10.20944/preprints202312.1184.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrating External Controls by Regression Calibration for Genome-Wide Association StudyDOI 10.20944/preprints202312.1184.v1Read

Integrating External Controls by Regression Calibration for Genome-Wide Association Study.Semantic proximity Read

Integrating external controls in case-control studies improves power for rare-variant tests.Semantic proximity Read

Improving power for rare-variant tests by integrating external controls.Semantic proximity Read

Novel score test to increase power in association test by integrating external controls.Semantic proximity Read

An efficient resampling method for calibrating single and gene-based rare variant association analysis in case-control studies.Semantic proximity Read

A data harmonization pipeline to leverage external controls and boost power in GWASSemantic proximity Read

ProxECAT: Proxy External Controls Association Test. A new case-control gene region association test using allele frequencies from public controlsSemantic proximity Read

A data harmonization pipeline to leverage external controls and boost power in GWAS.Semantic proximity Read

A general framework for meta-analyzing dependent studies with overlapping subjects in association mapping.Semantic proximity Read

Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies.Semantic proximity Read

Leveraging auxiliary data from arbitrary distributions to boost GWAS discovery with Flexible cFDRSemantic proximity Read

Improved Use of Small Reference Panels for Conditional and Joint Analysis with GWAS Summary Statistics.Semantic proximity Read