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Article

A data harmonization pipeline to leverage external controls and boost power in GWAS.

Human molecular genetics - 3 Feb 2022

Chen Danfeng, Tashman Katherine, Palmer Duncan S, Neale Benjamin, Roeder Kathryn, Bloemendal Alex, Churchhouse Claire, Ke Zheng Tracy

Abstract excerpt

The use of external controls in genome-wide association study (GWAS) can significantly increase the size and diversity of the control sample, enabling high-resolution ancestry matching and enhancing the power to detect association signals. However, the aggregation of controls from multiple sources is challenging due to batch effects, difficulty in identifying genotyping errors and the use of different genotyping...

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Identifiers

PMID: 34508597
DOI: 10.1093/hmg/ddab261
PMCID: PMC8825237

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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