Article
A general framework for meta-analyzing dependent studies with overlapping subjects in association mapping.
Human molecular genetics - 1 May 2016
Han Buhm, Duong Dat, Sul Jae Hoon, de Bakker Paul I W, Eskin Eleazar, Raychaudhuri Soumya
Abstract excerpt
Meta-analysis strategies have become critical to augment power of genome-wide association studies (GWAS). To reduce genotyping or sequencing cost, many studies today utilize shared controls, and these individuals can inadvertently overlap among multiple studies. If these overlapping individuals are not taken into account in meta-analysis, they can induce spurious associations. In this article, we propose a...
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